Abstract:
As is known, immune system disorders in HIV infection are of a systemic nature
and are manifested by imbalance and deep suppression of the T- and B-links of cellular
immunity, which leads to changes in both functional lymphocyte and
monocyte/macrophage activity and immediate and delayed hypersensitivity reactions,
humoral immunity and factors of nonspecific defense of the body. In the dynamics of
the disease, the functional insufficiency of CD8 + T-lymphocytes, neutrophils and NK
cells is increasing. Also, together with the deficit of CD4 + T-lymphocytes, the level
of serum immunoglobulin’s and circulating immune complexes, catabolism products
of cell receptors and changes in nucleic acids also increase. Clinically, changes in the
immune status are manifested by allergic, infectious, autoimmune and lymph
proliferative immunodeficiency syndromes that determine the clinical manifestations
of HIV infection.
