Abstract:
The most promising direction in the treatment of
chronic prostatitis is the use of medicinal plants and
preparations based on them, which contain natural
compounds with a broad spectrum of pharmacological
activity: anti-inflammatory, antimicrobial, reparative,
immunomodulatory, hormone-regulating, antisclerotic,
etc., and which can provide a complex therapeutic effect
on the course of chronic prostatitis. A promising raw
material in this direction is Tribulus terrestris L., a herbal
preparation traditionally used to treat erectile dysfunction
and atherosclerosis. This experimental work aims to study
the anti-inflammatory activity of a thick extract of the
Tribulus terrestris grass (freed from fruits) on the models of
carrageenan and zymosan inflammation in rats.
In the models of carrageenan and zymosan edema in
rats, a thick extract of Tribulus terrestris L. in doses from
50 mg/kg to 200 mg/kg shows anti-inflammatory activity,
the efficacy of which in the dose range of 150–200 mg/g
in the initial stages of carrageenan inflammation is not
inferior to sodium diclofenac at a dose of 8.0 mg/kg,
and in the initial stages of zymosan inflammation,
respectively, before the reference drug corvitin at
a dose of 10 mg/kg. It indicates the anticyclogenase and
antilipoxygenase properties of this thick extract.
