Видання іноземною мовою. Кафедра фармацевтичної хімії та технології ліків: Recent submissions

Зараз показуються 41-60 з 137

Unexpected conversion of 2-aminophenylacetic acid hexafluorosilicate to 2-oxindol under mild conditions

Lytvynchuk, I. V.; Fonari, M. S.; Kravtsov, V. Ch.; Gelmboldt, V. O. (2023)

Fluoride therapy is known to be the most effective and safe method of caries treatment. In recent years, ammonium hexafluorosilicates, including salts with biologically active cations, have been actively studied as ...
Pharmacodynamics of Interaction between Propoxazepam and a GABA-Benzodiazepine Receptor-Ionofor Complex

Golovenko, M. Ya.; Larionov, V. B.; Reder, A. S.; Andronati, S. A.; Valivodz’, I. P.; Yurpalova, T. O. (2018)

Effects of a propyloxy derivative of 1.4-benzodiazepine, propoxazepam, on GABA-benzodiazepine receptor complexes (GABA RCs) were examined in vitro and in vivo. The parameters of propoxazepam binding to synaptosomes from ...
The relevance of the development of a vitamin product from plant raw materials

Zamkova, A. V.; Borysyuk, I. Yu.; Molodan, Y. O.; Fizor, N. S.; Valivodz, I. P.; Rokun, D.-M. V. (2023)

The leading task of modern pharmacy is the creation and introduction of new effective drugs and the improvement of existing ones. At the same time, the development of easy-to-use, rational and therapeutically effective ...
Cross-species differential plasma protein binding of Propoxazepam, a novel analgesic agent

Golovenko, M. Ya.; Reder, A. S.; Larionov, V. B.; Andronati, S. A.; Akisheva, A. S.; Головенко, М. Я.; Редер, А. С.; Ларіонов, В. Б.; Андронаті, С. А.; Акішева, А. С.; Головенко, Н. Я.; Редер, А. С.; Ларионов, В. Б.; Андронати, С. А.; Акишева, А. С. (2021)

The purpose of this study was to characterize the Propoxazepam properties of binding to the human, dog and rat plasma proteins and to evaluate potential interspecies differences in binding affinity. Methods. The studies ...
Sedative-hypnotic and muscle relaxant activities of propoxazepam in animal models and investigation on possible mechanisms

Golovenko, M.; Larionov, V.; Reder, A.; Valivodz, I.; Tsapenko, Z. (2020)

Analgesic (for both neuropathic and nociceptive pain) and anticonvulsant action of 7-bromo-5-(o-chlorophenyl)-3- propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one (propoxazepam) make it perspective for further studying. ...
Pharmacodynamics of Interaction between Propoxazepam and a GABA-Benzodiazepine Receptor-Ionofor Complex

Golovenko, M. Ya.; Larionov, V. B.; Reder, A. S.; Andronati, S. A.; Valivodz’, I. P.; Yurpalova, T. O. (2018)

Effects of a propyloxy derivative of 1.4-benzodiazepine, propoxazepam, on GABA-benzodiazepine receptor complexes (GABA RCs) were examined in vitro and in vivo. The parameters of propoxazepam binding to synaptosomes from ...
Models of Introduction of Dual Professional Education

Kravchenko, O. L.; Borisyuk, I. Y.; Vakolia, Z. M.; Tretyak, O. M.; Mishchenia, O. M. (2020)

The dual system of vocational education is designed to balance education (in the educational institution) and training (at the enterprise level) equally in order to ensure the appropriate level of qualification, to teach ...
Synthesis, crystal structures, solubility and biological activity of 2-, 3-, 4-carboxyethyl pyridinium hexafluorosilicates

Gelmboldt, V. O.; Lytvynchuk, I. V.; Shyshkin, I. O.; Khromagina, L. M.; Fonari, M. S.; Kravtsov, V. C. (2022)

The fluoride-containing medical preparations dominate in the contemporary list of drugs for treatment and prevention of caries. Their efficacy and safety have been confirmed by results of clinical trials, as well as by ...
Effect of Both the Phase Composition and Modification Methods on Structural-Adsorption Parameters of Dispersed Silicas

Rakitskaya, T.; Kiose, T.; Golubchik, K.; Baumer, V.; Volkova, V. (2019)

Tripoli from two Ukrainian deposits was studied in its natural and modified forms. The investigation of natural and modified tripoli involves the identification of their phase compositions through X-ray diffraction and ...
Catalytic Compositions Based on Chlorides of d Metals and Natural Aluminosilicates for the Low-Temperature Sulfur Dioxide Oxidation with Air Oxygen

Rakitskaya, T. L.; Kiose, T. A.; Golubchik, K. O.; Dzhigaa, G. M.; Ennan, A. A.; Volkova, V. Y. (2018)

Samples of natural bentonite and clinoptilolite modi ed with copper(II), iron(III), and palladium(II) were characterized by both X-ray phase and the Fourier transform infrared spectral methods. The activity of monometall ...
Acid-modified clinoptilolite as a support for palladium–copper complexes catalyzing carbon monoxide oxidation with air oxygen

Rakitskaya, T. L.; Kiose, T. A.; Golubchik, K. O.; Ennan, A. A.; Volkova, V. Y. (2017)

Samples of natural clinoptilolite were modified by an acid–thermal method at nitric acid concentrations of 0.25, 0.5, 1.0, and 3.0 M and a contact time of 30 min. A series of catalysts, K2PdCl4–Cu(NO3)2–KBr/S (S = 0.25H-CLI, ...
The relevance of the development of herbal collection of antidepressant action

Zamkovaja, A. V.; Borysiuk, I. Yu.; Karim Yassim (2023)

According to the WHO, as well as based on the publications presented on the website of the electronic database of medical and biological publications «PubMed», there is an increase in the prevalence of diseases of the ...
The search for promising medicinal raw materials for the extraction of biologically active substances

Abd Elhaleem A.; Tsisak, A. O.; Borysiuk, I. Yu. (2023)

Medicinal plants have been a good source of new pharmacologically active molecules. Natural products could be a potential alternative for controlling the pathogen associated with diseases. Recently, antibiotics and ...
Innovative learning methods as factor of transformation of the educational process

Zamkova, A. V. (2023)

Innovative teaching methods introduce new methods of interaction in the teacher-student system, give novelty in practical activities when studing a certain discipline of group of disciplines, that is, it is a component of ...
The Impact of the COVID-19 Pandemic on the Education of Medical Students

Borysiuk, I.; Yaremkevych, R.; Sviatenko, T.; Striukov, V.; Krupskуi, O. (2022)

The study aimed to assess the effectiveness of distance learning for Ukrainian medical students during the COVID-19 pandemic. Universal and specific medical specialties problems of distance education is identified. The ...
Rights and obligations of regulators, drug manufacturers, doctors, pharmacists, patients, and insurance companies in the case of off label use of medicinal products

Panfilova, Н. L.; Drogovoz, S. M.; Sadovnyk, O. V.; Kalko, K. O.; Borysiuk, I. Yu.; Glushchenko, A. V.; Liulchak, S. Y.; Hainiuk, M. B. (2021)

For many years, the off-label use of drugs has been a debated issue for healthcare administrators, regulators, pharmaceutical manufacturers, doctors, pharmacists, insurance companies, and patients. The mechanism for ...
Manifestation of toxic action of paracetamol in female and male rats depending on the circadian rhythms of liver activity

Kalko, K. O.; Drogovoz, S. M.; Koyro, O. O.; Koyro, N. A.; Toziuk, O. Yu.; Lenha, E. L.; Bahan, S. O.; Borysiuk, I. Yu. (2021)

Today, the toxicity of paracetamol is very common, this is due to both the widespread availability of the drug and the misconception of its high safety. Paracetamol poisoning is the most common cause of severe acute liver ...
Range analysis, socio-economic accessibility and consumption of fibrates on the pharmaceutical market of Ukraine during 2017-2020

Mishchenko, O. Ya.; Kalko, K. O.; Оstashko, V. F.; Borysiuk, I. Yu.; Rokun, D.-M. B.; Rushchenko, O. O.; Bezdetko, N. V. (2021)

At present, statins are included in the first line of dyslipidemia therapy. Fibrates also take a certain place in the treatment of dyslipidemia. Given the above, it is advisable to study the pharmacoeconomic characteristics ...
Potential risks and pharmacological safety features of hypoglycemic drugs

Drogovoz, S.; Kalko, K.; Borysiuk, I.; Barus, M.; Horoshko, V.; Svyshch, O.; Liulchak, S. (2021)

For the treatment of diabetes, insulin preparations, synthetic hypoglycemic agents, herbal medicine and compulsory adherence to the diet. Oral hypoglycemic agents belong to different chemical classes: sulfonylurea ...
Docking analysis of the interaction of propoxazepam with diazepam and ibuprofen binding sites of human serum albumin

Golovenko, M. Ya.; Larionov, V. B.; Makarenko, O. A.; Borysiuk, I. Yu.; Valivodz, I. P.; Akisheva, A. S.; Головенко, М. Я.; Ларіонов, В. Б.; Макаренко, О. А.; Борисюк, І. Ю.; Валіводзь, І. П.; Акішева, А. С. (2022)

According to the results of molecular docking to the diazepam and ibuprofen binding sites of human serum albumin with the reference compounds – diazepam and ibuprofen, it was found that the compounds show crossrelatedness ...

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