The results of researches showed that patients who had been taking alcohol for a long time were observed to have sharply intensified formation of dien conjugates and malonic dialdehyde in comparison with the control of the same age as well as reduced activity of catalase, glutathione transferase compared with donors’ indices on the basis of these changes activity of urokaninase was determined in the system of POL-AOS in blood serum of females and males which is in impermissible fact and a sign of oxidative stress due to excessive accumulation of POL products and low activity of antioxidant enzymes. It results in destructive changes in the hepatic parenchyma which is confirmed by appearance of urokaninase in blood serum.
