The work is dedicated to the studying both of ethanol pharmacokinetic properties in mice after intravenous and intragastral administration and understanding some mechanisms for its penetrating to the brain.
The experiments were carried out on white male mice (22-24 g), which were administered 114С-ethanol (3 Cu/mol, 0,9 % NaCl solution, 20 mMol/kg) before. Radioactive material content in biological samples (plasma, brain, liver) was determined using the liquid scintillation photometry.
It was found that ethanol rapidly distributes in an organism (the half-distribution time (0.34±0.02) h for brain) and eliminates (half-elimination time (2.8±0.7) h). distribution between brain and plasma doesn’t depend on the administration way and equals 0.8–0.9 for brain and 2.3–2.5 for liver. The ethanol “dose-concentration” dependence in brain and liver is linear, that is due to its simple diffusion.