Common morphological features with spontaneous abortion are reduction of the level of cytotrophoblast invasive activity against reduction of utero-placental barrier and increased hypoxia, which leads to dystrophic and necrotic processes in the decidua and chorionic villi. Damage of large decidual cells accompanied by vacuolization of the cytoplasm, reducing the level of estrogen (ER) and progesterone (PR) receptors and prolactin (Prl), and may be a cause of abortion. Frustrated miscarriage morphologically is characterized by a pronounced inflammatory response and the presence of fibrinoid necrosis.
Immunohistochemical (IHC) analysis of the study also proves that pregnant women treated with the original hyperprolactinemia have regular decrease in hormone receptors. And the level of ER, PR, Prl receptors is regarded as low according to H-score. Critically low IHC-reaction occurs only in anembrionia, which is an unfavorable sign in the development and progression of subsequent pregnancies.