Ischemic stroke has some peculiarities; primary and secondary lesions are among them. In spite of wide arsenal of neuroprotective remedies, their clinical application in cerebral stroke is not always successful. It grounds the search for highly effective neuroprotectors. Pathogenesis of ischemic lesion of brain has some links, one of them is the development of nitrosating stress. The influence of the derivative of thioquinazoline NС-224 on thiol-disulphide system and expression of isoforms of NO synthase was studied on the model of experimental ischemia. Received data proved an ability of the derivative of thioquinazoline NС-224 to limit destructive effect of nitrosating stress.
