The article presents data on the study of the association of the genotypes of platelet receptor polymorphism P2RY12-744TT (H1H2) and their dependent changes in platelet function and proteolysis in patients with hypertension and type 2 diabetes mellitus. 100 patients with hypertension and diabetes type 2 and 50 patients with hypertension without diabetes were examined. Analysis of independent loci revealed a decrease in the frequency of carriers of “protective genotypes” P2RY12-744TT (H1H1) (p<0.05) in the studied population of patients with hypertension and diabetes mellitus type 2. It was found that the carriers of the “risk genotype” H2/H2 had increased rate of ADP-dependent and adrenaline-dependent platelet aggregation and a significant increase in the content of the XIII factor of coagulation. The proteolytic activity of plasma is significantly altered by the level of azoalbumin and azocasein with a decrease in the level of proteolysis in the case of the carrier of the “protective” H1 allele (p<0.05).
