Effects of most perspective compounds — derivatives of 4-thiazolidinones — Les-1205 — ethyl ester of ([2,4-dioxo-5-(thiazol-2-ylkarbamoylmethyl)-thiazolidin-3-yl]-acetic acid and Les-2658 — (5-(-nitrobenzyliden)-2-(thiazol-2-imino)-4-thiazolidinone have been investigated in the model of pentylenetetrazol (PTZ) — induced kindling. Both drugs have been used in two dosages — 50.0 and 100.0 mg/kg, i. p. in 30 min before PTZ administration. The pronunciation of antiseizure effects of Les-1205 (100.0 mg/kg) under conditions of developed kindling syndrome was comparable with those of diazepam in a dosage of 1.5 mg/kg ((2.88±0.23) and (2.5±0.3) score balls) correspondently), while in a dosage of 50.0 mg/kg it was comparable with diazepam effectiveness administered in a dosage of 0.5 mg/kg ((3.4±0.3) and (3.6±0.2) balls). Administration of Les-2658 in a dosage of 100.0 mg/kg did not prevent generalized seizure fits which have been observed in 6 out of 8 kindled rats ((3.75±0.16) balls).
