DEFINITION OF SUBTOXIC INFLUENCE OF PHOSPHORUS-CONTAINING ORGANIC MIXTURES ON THE REPRODUCTIVE FUNCTION OF RATS USING THE DOMINANT LETHAL MUTATIONS

Intact females were investigated: number of living embryos, places of resorption, corpora lutea of pregnancy. Calculations were made on the basis of analysis of embryonic material of pre-implantation, postimplantation and total embryonic animal death. Phosphorus-containing complex led to an increasing the pre-implantation death and in less degree to postimplantation embryos death. Studies show that xenobiotics are able to induce dominant lethal mutations of mature males of the first generation. The study revealed that phosphorus-containing organic mixtures reduced the number of living embryos and did not affect the number of resorption places and corpora lutea of pregnancy. Reducing the number of living embryos occurs as a result of both reducing the number of surviving zygotes and possible inhibition of fertilization, which is connected with the inhibition of reproductive function of male sperm.