The incidence of congenital malformations in children born in consequence of assisted reproductive technologies taking into account medical history

Abstract

Assisted reproductive technologies (ART) become more and more popular. The objective: to determine the frequency and structure of congenital malformations in children born as a result of application of ART (ICSI) with taking into consideration anamnestic factors. Materials and methods: 74 children born after ART (ICSI) aged 1 month – 7 y. o. were examined. The presence of CM is confirmed by the data of laboratory and instrumental investigations. Along with clinical examination of the children the analysis of the antenatal and perinatal period was carried out, particular attention was paid to the study of the preconceptual stage peculiarities. The results and discussion: In the structure of CM those of cardiovascular system predominated with the share of (72.2 ± 10.5)%. Ventricular septal defect was diagnosed in (4. 1±2. 3)% in the group of the children under examination and this exceeds the general population figures. The combination of cardiac defects with other anomalies was observed in (16.7 ± 8, 8)% of children. CM of the digestive system were mainly represented by small anomalies of development and were diagnosed in (13. 5 ± 3. 9)% of the children. CM of the urinary tract was detected in (5. 4 ± 2.6) % of the examined children. Congenital defects of the musculoskeletal system were detected in (8. 1 ± 3. 2)% of the children. Congenital defects of the CNS were diagnosed in (4, 1±2, 3)% of the children.