Colonization resistance of vaginal secretion

Abstract

Vaginal contents - vaginal secretion - this is a serous vascular transudate, a secret of the glands of the mucous membrane of the canine of the cervix and large glands of the vagina front, of the leukocytes and of the epithelium of the corpus luteum [1]. The main chemical composition of the vaginal secretion is water, inorganic salts, proteins (albumins, immunoglobulins), carbohydrates, fatty acids, urea, lysozyme [2, 3, 8]. Physiological maturation of epithelial cells, accumulation of glycogen in them and securing the acidity of the vaginal secretion are affected by estrogen. To the protective mechanisms of the vagina are physiological white, the normal amount of which per day is up to 2 mg; A normal microflora of the vagina is present in the form of lactobacter bifidobacteria, which compete with the vaginal microflora for glycogen and create an acid medium. A key factor is the so-called "colonization resistance of the vaginal secretion," which includes the protective agents that enter humoral pathway here and are produced by local lymphoid tissue (IgA, IgM, IgG, lysozyme, a-lysines, complement, secretory IgA, etc.), bactericidal compounds hydrogen peroxide, lactic acid), cells of the immune system (leukocytes, macrophages, T- and B-lymphocytes) [4, 5, 6]. The purpose of the work was to study cellular and humoral indices at normal norms and at different levels of dysbiosis.