Peculiarities of specific migration of human blood monocytes in response to atherogenic immune complexes in vitro conditions have been investigated. The study has been carried out on primary culture of blood monocytes from healthy donors with the use of Boyden camera. It has been shown that immune complexes were strong chemoattractants relative to monocytes, but direct interaction of these agents with mononuclear cells decreased the locomotor functions of the latter. The early and principally important stage for the initiation of monocytes chemotaxis in response to immune complexes is activation of formation of cyclic AMP and cleavage of phosphatidylinositol-4.5-bisphosphate with the subsequent production of biologically active metabolites. Calcium antagonists (nifedipine) markedly decrease monocytic migration in response on immune complexes.
