Morphohistochemical researches of the rats’ liver after DDE introduction are carried out. It was established, that in liver cells hydropic dystrophias resulting in destructions and losses of a part of hepatocytes develop. One of the toxic effects of DDE was the cell’s genetic apparatus damage and, as a results, the atypical mitosis forms formation. The compensative-reparative processes in the liver were sufficiently active and they were carried out exclusively by the way of hepatocytes mitotic proliferation.