The analysis of the biochemical blood of 29 patients suffering from acute flegmonous calkulous cholecystitis complicated by bile peritonitis has shown that surgical treatment of severity degrees ІІІ А, ІІІ B of this disease is characterized by improvement of the parameters of a biochemical blood analysis with the formation of positive correlations between the urinary concentration and the activity of aspartate aminotranspherase, the activities of aspartate aminotranspherase and alanine aminotranspherase for degree ІІІ А and directly proportional correlations between the activity of alkaline phosphatase with alanine aminotranspherase and gamma-glutamyltranspeptidase for degree ІІІ B.