On preadolescent male white rats the influence of pyracetam and memantin was investigated at their incorporated introduction of peroxide protein oxidation, Nа+, К+-ATPase activity, lactatedehydrogenase activity in the main brain by modeling acute hypobaric hypoxia. It is established that acute hypoxia assists authentic increase in the level of secondary products of peroxide protein oxidation, lactatedehydrogenase activity and decrease in Nа+, К+-ATPase activity in comparison with the control group of animals. The simultaneous pyracetam and memantin introduction after hypoxia authentically reduces the level of secondary products of peroxide protein oxidation, lactatedehydrogenase activity and raises activity of Nа+, К+-ATPase in comparison with the separated applecation of the drugs.
