Laparoscopic treatment of chronic pancreatitis complications (42 patients) causes less pronounced deteriorations in the functional state of thiol-disulphide system of the blood in comparison with traditional treatment (25 patients). A relatively higher level of thiol groups along with less significant increasing of disulphide groups was kept both in non-protein and protein fractions of blood and in blood serum. The usage of pentoxyphyllinum in the complex therapy (0.1–0.2 g, i. v. daily during 7 days) significantly improved indices of functional state of the thiol-disulphide system in postoperative period (22 patients).