40 patients suffring from exertional angina pectoris of II–III functional classes (FC) who administered atorvastatin in the dose of 20 mg a day were examined. It was revealed that contents of dien conjugate (DC) decreased and glutathione reductase activity increased. The contents of renewed thiol compounds in the blood plasma increased too. The patients who were not administered statins developed DC increase, and antioxidant defence intensification in the blood plasma was not detected.