It is investigated corrective action of a polyphenolic drug altan on character of the structurally functional changes arising in the tunica mucosa (TM) of rats’ mouth during combined action of delagil and emotional-painful stress under conditions of insufficiency of alimentary plant polyphenols. Positive influence of drug on structures of vessels of the microcirculatory bloodstream, subepithelial connective tissue and integumentary epithelium of TM of mouth is shown. It is established, that reparative changes induced by altan are realized by endocellular regeneration in a combination with expressed compensatory hypertrophy of a part of epithelium integument cells.