THE COMPARATIVE CHARACTERIZATION OF THE DISTRIBUTION CONSTANTS FOR ETHANOL AND ITS METHABOLITES, DETERMINED BY THE METHODS OF ASYMPTOTIC APPROXIMATION, AREAS UNDER THE CURVES AND THEIR COMBINATION

The using of the distribution constants between organs and blood because of its physiological base is one of the useful methods for substance mass-balance evaluation. The aim of this work was comparative estimation of distribution constant determination methods for ethanol, acetaldehyde and acetic acid.

Experiments were carried out on white male mice. 14C substances were administered intragastrally and intravenously in different doses. The radioactive compounds quantity was detected with the liquid scintillation photometry.

It was shown that combination of both asymptotic method and method of areas under the curves is the most useful for distribution constant determination.