At chronic cardiac insufficiency of severe degree, which arise during ischemic heart disease, both before and after basic therapy, in comparison with ischemic heart disease without chronic cardiac insufficiency it is established: a decrease in defensive function of polymorphonuclear leukocytes in the blood, their lytic activities and complement system activity; an increase in contents of ІL-1, ІL-4, ІL-6, TNF-α cytokines, a decrease of integral СD3+-T-lymphocytes pool, due to disbalance in number of СD4+ and СD8+ T-cells; an increase in production of IgG and lowmolecular circulating immune complexes, which testify to further disturbances of specific and nonspecific immunologic reactivity.
