PECULIARITIES OF SWIMMING AND AGRESSIVE BEHAVIOR OF RATS WITH SUBARACHNOIDAL BLEEDING UNDER CONDITION OF TREATMENT WITH L-ARGININ AND PENTOXYPHYLIN

The number of rats in 24 h from the moment of modeling subarachnoidal bleeding (SAB), which were able to demonstrate more than three elements of passive-adaptive patterns of swimming, was shortened 2.4 times as much when compared with the control. Combined usage of L-arginin (200.0 mg/kg, i. p.) and pentoxyphyllin (PTPh) (25.0 and 50.0 mg/kg, i. p.) was followed by the raising of the number of rats, which demonstrated three and more patterns of passive-adaptive swimming by 2.15 and 2.4 times correspondently when compared with rats which have not been treated, and that index was greater than in case of separate usage of pharmacons. Potentiated effect of treatment was observed with the respect of ability of rats to escape from pool, and the reduction of the threshold of escape was 2.53 and 2.26 times. Combined usage of pharmacons increased the threshold of aggressive reactions 1.7 and 2.1 times as much in comparison with the analogous indices registered in rats with SAB without treatment.