This paper provides an assessment of the clinical effectiveness of treatment of acute infectious myocarditis in 89 children aged from 3 to 16 years using different regimens of therapy. It was conducted comparative analysis of clinical and paraclinical parameters in four groups of children. With the clinical-laboratory, instrumental and statistical methods it was proved a true preference of complex of treatment of acute infectious myocarditis in children with inclusion of drugs with antihypoxic and antioxidant action in standard therapy.