THE INFLUENCE OF ISONIAZID ON THE STATUS OF LIPIDS PEROXIDATION IN THE PATIENTS WITH TUBERCULOSIS

The goal of present work was an investagtion of putative correlation between pharmacokinetics of the antituberculosis drug isoniazid and the level of pro- and antioxidant systems markers in patients with tuberculosis (TB).

Isoniazid concentration was detected in venous blood 2, 4, 6 and 24 hrs after ingestion of standard dose according to Vollenberg method with modification of R. I. Shenderova. For detection of acetylation genotype the N-acetyltransferase-2 polymorphism was analyzed. The blood samples were obtained from 84 TB-patients with new cases from Odessa regional antituberculosal dispensary in 2012.

According to obtained data, the decreasing of isoniazid concentration in TB-patients associated with declining diene conjugates level and enhancing catalase activity. The isoniazid concentration, AUC and terminal elimination of isoniazid were in direct correlation with diene conjugates level. The catalase activity and antioxidant index 6 hrs after isoniazid intake were in direct correlation with initial elimination and in direct correlation with terminal elimination of isoniazid. The significant difference in status of pro- and antioxidant systems in carriers of different acetylation genotype during isonisazid usage was absent.