Based on research data it was evaluated immune and cytokine state in children with purulent inflammatory processes before and after complex therapy, which was held for 10 days and included various combinations of cytokine corrector ronkoleukin, immunomodulator polyoxidonium and antimicrobial drug cefepim.
A significant increase in the neutrophils phagocytic activity and IgA concentration in the serum of children with purulent inflammatory processes receiving combined therapy of cefepim with ronkoleukin and polyoxidonium was shown. All markers of inflammation in children with purulent processes receiving complex therapy including cefepim + polyoxidonium or cefepim + ronkoleukin were significantly higher (p<0.001), than in group of healthy children or in a group of children who received cytokine corrector and immunomodulator together with an antimicrobial agent. Reduce in levels of proinflammatory cytokines (TNFα, IL-1β) and C-reactive protein in the group of children who received therapy with cefepim, ronkoleukin and polyoxidonium indicates a decrease in inflammatory process intensity in children with purulent processes.