Rats were tested to check the muscular dysfunction complex pathogenetically oriented pharmacological correction efficacy in conditions of subarachnoid haemorrage (SAH) due to i. p. pentoxifylline (PTF, 50 mg/kg) and L-arginine (L-A, 500 mg/kg) separate and combined administration. SAH model was reproduced through autoblood bilateral stereotactic injection into the brain parietotemporal region and additional autoblood (0.3 ml) intracisternal administration.
Muscular activity was determined by the rats’ ability to keep position both on a horizontally rotating grid (rotarode) and on the surface ‘raised mesh’ at the angle of 80°. Both PTF and L-A injected separately were shown to reestablish equally rats’ muscular tone and coordinative activity. After their coadministration muscular dysfunction has been eliminated in all animals that was registered during 72 hrs, therefore one could conclude about muscular dysfunction complex pathogenetically oriented correction in conditions of SAH performed out and its efficacy was tested after PTF and L-A combined administration.