The aim of the study was to evaluate the association of SMAD7 gene polymorphism with morphological changes in the liver in chronic viral hepatitis of various etiologies.
The study involved 31 patients with chronic hepatitis of mixed etiology (B + C). Molecular genetic studies included the determination of polymorphic variants of the gene SMAD family member 7 (SMAD7 C>T).
As a result of the pilot studies, it can be assumed that the genetic component of severe fibrosis in patients with hepatitis of various etiologies is not significantly different: in all groups under study, the degree of F3 fibrosis is associated with СT allele SMAD family member 7. This index can be used as an additional criterion in the diagnosis and prognosis of chronic liver disease.