Electroretinographic characteristics of the retina state in experimental diabetes under conditions of treatment with new derivative niacin-oxietilyden-diphosphonate germanate (NicH)2 [Ge (OH)2 (Oedph)] were studied. H20 (MIGU-4) being delivered together with electrical stimulations of paleocerebellar cortex.
Exeprimental diabetes was modeled via i. p. streptozotocin (STZ) (“Sigma Aldrich ru”, 50 mg/kg) administration. MIGU-4 was adiministered in dosages of 5.0 and 25.0 mg/kg, i. p. daily. ESs (100 Hz) of V-VII lobules of paleocerebellar cortex were performed one time per day. Electroretinography was performed in 12 weeks from the moment of STZ administration.
The treatment with MIGU-4 (25.0 mg/kg, i. p.) prevented diabetes induced deteriorations of electroretinogram. The combined usage of not-effective paleocerebellar ES as well as low dosage of МIGU-4 (5.0 mg/kg, i. p.) effectively prevented deteriorations of latency and amplitude of potentials identified in retinogram of rats with experimental STZ-induced diabetes.