ESTIMATION OF BIOTRANSFORMATION OF AMINOMETHILIZONONILFENOL AND ITS HYDROXYETHYL DERIVATIVES AT SUBACURE PERORAL INTRODUCTION TO RATS

A research aim was to estimate in a subacute experiment influence of aminomethilizononilfenol and its hydroxyethyl derivatives with the number of oxygen groups 4, 12 in a dose 1/100 LD50 on the indexes of microsome oxidization in the liver of rats.

It is well-proven that the investigated chemicals in a dose 1/10 LD50 yield biotransformation in the organism of rats in a dose of 1/100 LD50 on the 30th day of introduction to the rats cause the increase of activity of microsome oxidization in hepatocytes. Such changes are the protective reaction of organism to foreign chemicals. It is educed that AMINF and its hydroxyethyl derivatives in a dose 1/100 LD50 at the end of subacute experiment assist the increase of no-enzyme iron-ascorbic-dependent (on the average 3.5 times) and fermentation NADPН-dependent (2.4 times) LPO in microsoma of liver of rats, that assists to development of oxidizing stress.