LIFETIME OF TISSUE IN ASPECT OF THE MATHEMATICAL LAW OF AGEING

The data about age changes of density of the endothelial cells of the cornea received by means of the multi-analyzing mirror microscope is presented. The data of 286 corneas from 196 corpse donors at the age from 20 till 70 years, with the subsequent analysis of results in aspect of a mathematical model of ageing, is studied.

Viability of a cornea is its ability to sustain a transparency that is connected with number (density) of cells of endothelial monolayer. This ability drops with age simultaneously with reduction of number of cells. But as during age the cellular number descends according to the formula of exponential disintegration, as the presented data testify, it is possible to assert that loss (elimination) of cells has age-independent character, i. e. is not caused by ageing of cells. Thus, ageing of histic system, which shows the endothelial monolayer, is possible to describe by the formula of exponential disintegration. Supervision of the age changes of the cellular number, having age-independent character, testify it.