As a result of complex researches it is established, that acute cholestasis causes amplification of lipid peroxidation reactions result in deep violations of cycles adenosinmonophosfate system functional condition. It is known, that changes of this system function cause posttranslation modification of chromatin proteins reaction disturbances and damage both hepatocytes nuclei genetic apparatus and liver cells cytoplasm. Decompressive operation was the most effective for liver structure regeneration during first 24 hours after occlusion. Reparative activity possibility of liver parenchime after 48 hours duration cholestasis and decompressive operation was limited. The negative shifts of occlusion largely looses after heptral injection and amplification of liver parenchime reparative processes was revealed.
