Acute experimental pancreatitis development peculiarities were studied on the pancreatic gland traumatically-induced model of the disease in rats. Blood nitric-containing substances content, plasma proteolytic enzymes activity, ascitic fluid volume and weight, macro- and histological pathology as well as plasma tumour necrosis factor (TNF-α) and interleukin-1 (IL-1β) were investigated on the background of the NG-nitro-L-arginin preliminary administration. NG-nitro-L-arginin (20 mg/kg) injection lead to blood nitric-containing substances content decreasing, plasma enzymes deteriorations, pancreatic macro- and microindices disappearing. Plasma TNF-α and IL-1β levels were significantly increased in rats with experimental pancreatitis which failed to change after NO-synthase inhibitor administration. Thus, authors proved the endogenous nitric oxide system important role in acute experimental pancreatitis pathogenesis.
