DETERMINATION OF THE IRREVERSIBLE BINDING OF 3H-AMYXIN IN THE ORGANS AND TISSUES OF MICE

Study of the amyxin distribution process at intravenous injection and oral introduction to mice has shown that there are two phases in the compound pharmacokinetics: the first phase is the penetration of the medicine into the examined organs; the second phase is the elimination of the compound from the organism during the studied time interval.

The maximal content of general radioactivity was observed in the liver and kidneys of experimental animals, the minimal — in the blood plasma for the both ways of amyxin introduction. For the liver and lung tissue of experimental animals at amyxin introduction the effect of the initial passing through organs was observed. Accumulation of the content of [3H]-products in the spleen of animals was found in case of increasing of the experiment’s time.