The effect of L-arginine, the main substrate of NO synthase, Nw-nitro-monomethyl-L-arginine (L-NMMA) and Nw-nitro-L-arginine methyl ester (L-NAME) — the non-selective inhibitors of all NO-synthase isozymes, as well as selective inhibitor of the inducible form, aminoguanidine, on aggregation and ultrastructural characteristics of the platelets in vitro and in vivo were studied in the normal state and in diabetes mellitus. The anti-aggregation effect of L-arginine was found to be stronger in vitro. The protective effect of aminoguanidine on the platelet structure under insulin-dependent diabetes mellitus was observed.
