Hyperhomocysteinemia (HHC) is an independent risk factor of atheriosclerosis origin, ischemic heart disease thrombosis and vascular occlusion. The search of hyperhomocysteinemic action preparations is restreined by the absence of corresponding experimental models, which would take into account the main pathogenetic mechanism of HHC origin. In this article there are given three models of HHC created by authors: two — methionite (acute and chronic loading by methionine) and one — combined, caused by methionine introducing on the background of relative dificiency of vitamines B6, B9, B12. It is shown that, vitamines B6, B9, B12 in doses that exceed physiologic need in five times, are able to descrease or completely normalize the level of homocysteine in blood plasma of animals with HHC.
