This work is dedicated to the possibility of the 1.4-benzdiazepine derivatives transdermal delivery for abstinent syndrom correction studying.
It was found that first subconvulsive phase is effectively eliminated after transdermal phenazepam administration, though the second phase is obviated after 3-hydroxyphenazepam administration. Phenazepam and 3-hydroxyphenazepam increase the pentylentetrazol doses to the control values in both subcunvulsive phases.