The work is dedicated to studying dynamic of indices of different links of the immune system correlating with indises of molecular changes in blood serum in conditions of simultaneous toxic hepatitis and antigenic stress, studied by laser correlative spectroscopy.
It was ascertained that CCl4 is not only hepatotoxic but also immunotoxic and depresses the immune response on all phases of its forming. It’s clear from LC-histograms that introducing of hepatic toxin simultaneously with rat’s immunization leads to more marked depressing of immune response on foreign antigen. LCS method is a reliable integral index of homeostasis. It also correlates with accepted biochemical and immunologic methods. LCS is a sensible method, it allows noting and fixing the less deviations of homeostasis, which can’t be found out by standard methods. Antigenic stress and autoimmune process in the case of toxic hepatitis can be seen on LC-histograms.