Findings of experimental studies of anticancer and antimetastatic efficacy of syngeneic spleenic dendritic cells (DC) on models of inoculated tumors in mice are presented. It is found that maximal anticancer and antimetastatic effect have DC, loaded with syngeneic tumor antigen at their intravenous (i/v) administration. In case of their preventive i/v administration respectively to inoculation of tumor such DC promote formation of protective anticancer immunity in animals with tumors that results in prolongation of their survival.
