The functional activity of macrophages, activity of cathespin D in these cells, liver and cerebrum have been studied in the dynamics on the model of experimental allergic encephalomyelitis. The histological assay has shown an activation of inflammatory and destructive processes in cerebrum. These processes are followed with the increase of cathespin D activity in cerebrum and liver in the EAE dynamics. The perivascular infiltrations of cerebrum with monocytes and changes in functional state of macrophages out of CNS have been detected.
