The action of EKSO — a preparation of isoflavonoids obtained from soy-beans — on the structure of the uterine wall in ovariectomy conditions was discovered by the morphological and morphometric methods. It was established the named preparation effects like protector on the tissues of endo- and myometrium preventing the atrophic changes development. The surface epithelium and the glands of the endometrium preserved their usual shape and structure and did not transform under the hormonal homeostasis disturbance in the case of EKSO usage. In the other case the sizes of the cells, their structural components and nucleic acids content in the cytoplasm changed significantly. It is important that the preparation didn’t influence much on the mitotic division of the cells and the hyperplasticity of the endometrium. The obtained data show soft estrogen-like effect of EKSO and permit us to think of perspectives of EKSO usage in substitute therapy with the estrogen.
