On the 4, 6 and 8th week histological findings were fulfilled. from the beginning of the 4th week there was observed moderate gliosis of retina with partial loss of neuron stratification with fibroblastic metaplasia of pigment epithelium. Then proliferative changes progressed and to the end of experiment on the all eyes we could see total retinal detachment with severe tractional component and massive focus of Schiff positive reaction (epiretinal membranes). Also, it was proliferation of pigment epithelium with fibroblastic metaplasia and formation of hyaloid-liked membranes with well-expressed Schiff positive reaction in the parts of fibroblastic metaplasia. Proliferative changes that were modeled are closed to the same in clinic. The model can be used for assessment of effectiveness of antiproliferative agents.
