To clear up the question concerning a possible role of uric acid (UA), its serum concentrations along with the certain indicators of lipid peroxidation status blood malonic dialdegidum (MDA) and erythrocytes superoxiddismutasa (SOD) were investigated in 50 CF and 23 healthy children.
There was revealed a significant elevation of UA serum levels with strong correlation with hypoxia markers severity on background of tendency to the decrease of SOD activity in combination with considerable reduction of MDA plasma concentrations.
The obtained data allow to make a conclusion about possible compensatory hyperuricemic component existence, directed to replacement of functional insufficiency of the definite impaired links of antioxidative system in hypoxic conditions.