The work is dedicated to pathological changes of pancreatic tissues of rats with L-arginine-induced acute experimental pancreatitis and morphological tests of therapeutic effects of different forms of dalargin and NG-nitro-L-arginine. Nitric oxide synthesis blockade by NG-nitro-L-arginine dose-dependently normalizes macro- and microscopic changes in pancreatic tissue. The obtained data indicate that using of free and liposomal forms of dalargin, with therapeutic aims, in conditions of results in processes of macro- and microscopic changes in pancreatic tissue normalization efficacy significantly prevails the same of peptide’s free form. This positive effect is the experimental background in clinical use of nitric oxide blocking and liposomal form of dalargin for treatment of acute pancreatitis.
