It was studied interferonogenesis in adult and old mice, infected by sublethal dose of grippe A virus in different stage of stress-syndrome. It was established that chronic stress in early stage stimulated virusinduced interferonogenesis in adult mice and increased its resistance to sublethal viral infection. In old mice we observed depression of interferonogenesis after the first day of experimental old mice didn’t demonstrate the resistance stage of stress-syndrome with increasing of antiviral activity. A chronic 4-day stress leads to global depression of antiviral activity and generalization of viral infection, transforms a sublethal dose to a lethal one. Old animals had more expressive changes of antiviral activity at the early stage of a chronic stress-syndrome.
