The peculiarities of white rats’ renal activity as well as the condition of renal transport under condition of prolonged usage of sodium nitrite water solutions were researched. The white rates with the body weight of 130–170 g were given sodium nitrite water solutions in concentration of 20 and 60 mg/l (1st and 2nd group) during 10 days. The renal activity was examined under conditions of 5% water load. The rats of the 1st group had increased speed of glomerular filtration and sharply strengthened proteinuria. The 2nd group rats had decreased speed of glomerular filtration, moderate proteinuria, increment in renal losses of the osmotically active substances and two-fold decrease in creatinine concentration index.
