In experiments on 36 albino nonlinear male rats, weighing 0.16–0.18 kg it has been established that the use of the GA-40 medication results in a normalization of the characteristics of intensity, ellipticity, the birefringence index of a crystalline substance: median value, dispersion, asymmetry, excess in the cortical, medullary substance and renal papilla, preventing the development of tubulo-interstitial syndrome on the 30th day of sublimate nephropathy. More sensitive criteria for an evaluation of the antinephrosclerotic effect of the GA-40 medication in case of tubulo-interstitial syndrome based on the degree of an influence on the content of a crystalline substance as a marker of collagen, are asymmetry and excess than median value and dispersion.
