The goal of the present study was to evaluate the spreadness of drug-resistance and meaning of genotyping detection of isoniazide-resistance on the example of the Odesa region with the help of a simple multiplex allele-specific polymerize-chain reaction.
During 2000–2006 in the Odesa region there is a significant rise of drug-resistance to the I line antituberculosis agents. Among isolates that are resistant to isoniazid approximately 87.0 % had mutation in codon 315 katG. Spreadness of Beijing family was 43.1 %, that exceeds a bit the data of 2003 (39.6 %).
Detection of isoniazid-resistance at codon 315 gene katG, given in the article, after certain improvement, can be recommended as screaning-test for isoniazid-resistance.