Diabetes mellitus (DM) was caused in 20 white rats at the age of 6–8 months by the intraperitoneal introduction of 40 mg/kg of streptosotocyn (C). In 10 and 25 days after the introduction of C the activity of proteases (by caseolysis at рН 7,6) in homogenates of liver, pancreas as well as in blood serum, was studied.
Twenty other rats since the 2nd day after the introduction of C have received the preparation of inulin from chicory roots by 2 g/kg per os. It was determined that the development of DM reduces the proteolytic activity in pancreas and increases it in the liver. In 25 days the activity of protease normalizes in the pancreas, and almost twice decreased in the liver. The introduction of inulin prevents the decrease in level of proteases activity in pancreas and its rise in the liver.
The activity of proteases in blood serum in rats by the 25th day of DM grows almost 6 times as much. Inulin influences this activity slightly.