The involvement of development the regular interictal spikes (IS) in the rat’s hippocampus and frontal cortex on the generation ictal discharges with severe behavioral seizures in a chronic kindling model were investigated.
The most commonly observed pattern (67% of rats) was characterized by the appearance of regular IS. In the case when we observed single IS, non-regular IS progressed into generalized clonic-tonic seizures after 14th–17th injection of PTZ. During this time of kindling procedure the development of severe generalized clonic-tonic seizures hasn’t been found in rats with regular IS.