In acute experiments on male Wistar rats it was shown that i.p. administration of bacterial lipopolysaccharide (LPS) (0.01–1.0 mg/kg) caused the facilitation of generalized clonic-tonic seizures development, induced with benizlpenicillin sodium salt administration (3.0 mln IU/kg). This effect was observed in 2–4 h from the moment of epileptogen injection and was substituted with the suppression of seizures in 12–18 h. Clonic seizures, which were induced by kainic acid administration, have been intensified by LPS both in early and postponed period of observation.
